BEIJING, Feb. 08, 2026 (GLOBE NEWSWIRE) — InnoCare Pharma (HKEX: 9969; SSE: 688428), a number one biopharmaceutical firm specializing in the therapy of most cancers and autoimmune illnesses, introduced in the present day that the Heart for Drug Analysis (CDE) of the China Nationwide Medical Merchandise Administration (NMPA) has accepted the Investigational New Drug (IND) utility to conduct scientific trials of ICP-538, a VAV1-directed molecular glue degrader (MGD). That is the primary VAV1 degrader accepted to enter scientific trials in China and the second globally.
ICP-538 is a novel, potent, extremely selective, orally administered molecular glue degrader focusing on VAV1, a key protein downstream of T-cell and B-cell receptors, for the therapy of autoimmune illnesses, similar to inflammatory bowel illness, systemic lupus erythematosus, and a number of sclerosis. ICP-538 induces speedy and environment friendly degradation of VAV1 protein in a dose-dependent method by selectively mediating the formation of a ternary complicated between the CRBN E3 ubiquitin ligase and the VAV1 protein. At the moment, there are not any accepted VAV1-targeted therapies globally.
Degradation of VAV1 can successfully inhibit T-cell proliferation, differentiation, activation, and cytokine launch, in addition to B-cell activation and cytokine launch, thereby exerting anti-inflammatory and immunomodulatory results and assuaging autoimmune and inflammatory pathological processes. Preclinical research have proven that ICP-538 induces deep degradation of VAV1, resulting in a major discount in cytokines related to immune-mediated illnesses, with no detectable results on different proteins.
Dr. Jasmine Cui, the Co-founder, Chairwoman, and CEO of InnoCare, mentioned, “InnoCare has been growing novel medication for the therapy of autoimmune illnesses. As a novel focused therapeutic agent, the VAV1 molecular glue degrader presents three main benefits: excessive goal selectivity, mediation of a number of mechanisms of motion, and excessive efficacy, which is anticipated to develop into a promising new therapeutic possibility for sufferers with autoimmune illnesses.”
About InnoCare
InnoCare is a business stage biopharmaceutical firm dedicated to discovering, growing, and commercializing first-in-class and/or best-in-class medication for the therapy of cancers and autoimmune illnesses with unmet medical wants in China and worldwide. InnoCare has branches in Beijing, Nanjing, Shanghai, Guangzhou, Hong Kong, and the USA.
InnoCare Ahead-looking Statements
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