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    Home»Healthcare

    Healthcare Deals 2025: Notable Mergers & Acquisitions Activity

    M PansareBy M PansareFebruary 26, 2026 Healthcare No Comments6 Mins Read
    Healthcare Deals 2025: Notable Mergers & Acquisitions Activity
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    Regional Medical Center and Santa Clara Valley Healthcare

    The County of Santa Clara kicked off April with the $150 million acquisition of Regional Medical Center in San José, Calif. The 258-bed hospital is now operated by Santa Clara Valley Healthcare. The county has reinstated the hospital’s Level II trauma center status and brought back stroke and STEMI care. It plans to bring back labor and delivery care in the future.

    “This community — rich in culture and resilience — has long faced disparities in access to trauma care, stroke response, and maternal health. By bringing RMC into the County system, we are restoring and expanding vital services where they are needed most. This is more than a hospital — it’s a commitment to equity, dignity, and health justice for our most vulnerable residents,” said Sylvia Arenas, District 1 supervisor for Santa Clara County, in a press release.

    Baptist Memorial Health Care and Arkansas Methodist Medical Center

    In April, Baptist Memorial Health Care in Memphis, Tenn., and Arkansas Methodist Medical Center in Paragould, Ark., signed a letter of intent to merge. They expect to finalize an agreement by early 2026.

    “Arkansas Methodist Medical Center has similar values to Baptist Memorial Health Care and an excellent reputation in the community. By combining our organizations, we can expand the reach of sustainable and quality health care in the region while creating a strong organization with the size, scale, technology and intellectual capital to expand access to care while weathering future challenges,” said Jason Little, president and CEO of Baptist Memorial Health Care, in a statement.

    Atlantic General Hospital and TidalHealth

    In May, two Maryland-based healthcare providers announced their intent to merge. Atlantic General Hospital in Berlin, Md., will merge with TidalHealth, based in Salisbury, Md., under the TidalHealth name. As part of the transition, Atlantic General’s electronic health record will be converted to Epic in order to “enhance coordination and access for patients,” according to the announcement.

    “Healthcare systems are more frequently coming together to meet the challenges of an ever-evolving environment. We are proud to now have officially partnered with an organization that has very similar philosophies and beliefs, and together we will be working throughout the region to improve health and wellness across the continuum of care,” said Steve Leonard, president and CEO of TidalHealth in a press release.

    UnityPoint Health and MercyOne Siouxland Medical Center

    UnityPoint Health, a nonprofit health system with locations in Iowa, Illinois and Wisconsin, announced in May that it plans to acquire MercyOne Siouxland Medical Center in Sioux City, Iowa. The acquisition would include the medical center, its medical group and home care services. It is expected to be completed this summer.

    TriHealth and Clinton Memorial Hospital

    TriHealth, a health system in Cincinnati, recently announced plans to acquire Clinton Memorial Hospital in Wilmington, Ohio. CMH will be TriHealth’s sixth acute care hospital.

    “Bringing CMH into the TriHealth system is an exciting next step in this partnership as it will enable us to collaborate more closely with local physicians to extend TriHealth’s nationally recognized service lines, innovative population health care models, and world class specialists to Clinton County, all to serve more patients, better in the local community while creating seamless access to the most advanced tertiary care when needed,” said TriHealth President and CEO Mark C. Clement in a statement.

    Firelands Health and The Bellevue Hospital

    Firelands Health, based in Sandusky, Ohio, officially took over control of The Bellevue Hospital, based in Bellevue, Ohio, in May. The Bellevue Hospital filed for Chapter 11 restructuring in early February due to rising operational costs, regulatory complexity and funding constraints, according to a press release.

    Firelands Health has pledged capital investments in the hospital to maintain its services and ensure continuity of care, according to a press release announcing the new ownership.

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    Pender Community Hospital and Bryan Health

    Two Nebraska-based hospitals announced an affiliation agreement in June. Pender Community Hospital and Bryan Health hope to strengthen healthcare access and quality for rural communities in the state.

    “Rural areas of our Midwest and state face unique healthcare challenges that require dedication, partnerships, and creativity,” said Pat Ganyo, vice president of Bryan Health System, in a press release. “Through our decades of providing care and outreach throughout all corners of Nebraska, Bryan Health understands that one size does not fit all and each community or region has its own unique challenges and opportunities. We are honored Pender Community Hospital selected and trusts Bryan Health to assist in providing operational support, outreach and serving their patients in Northeast Nebraska.”

    Through PCH’s affiliation with Bryan Health, it will have access to new training and development opportunities for clinicians and support staff.

    Howard University and Adventist HealthCare

    In early June, Adventist HealthCare announced that discussions regarding its acquisition of Howard University Hospital (HUH) in Washington, D.C., have ended and the management services agreement between the two organizations, which will be phased out by February 2026.

    “The collaboration between Howard University and Adventist HealthCare over the past five years has resulted in a number of significant achievements and continued to build upon Howard University Hospital’s legacy of delivering excellent care to our community and leadership in education and research,” said Howard University President Ben Vinson III in a statement. “While Howard and Adventist have mutually agreed to discontinue Adventist’s management of the Hospital and Faculty Practice Plan, the University will continue efforts to secure a future partnership.”

    Howard University will take over operations at HUH, which the organization doesn’t expect to impact patient care.

    OHSU and Legacy Health

    Oregon Health & Science University, an academic medical center, and Legacy Health, a nonprofit health system, called off their merger plans in May, nearly two years after announcing their intent to integrate.

    “After careful consideration of the evolving operating environment, the organizations have determined that the best way to meet the needs of the communities they serve is to move forward as individual organizations,” reads a statement about the transaction’s termination.

    Phelps Health and Salem Memorial Hospital

    Two Missouri-based organizations have ended discussions about a possible affiliation. Phelps Health in Rolla, Mo., and Salem Memorial District Hospital in Salem, Mo., announced a possible affiliation in August 2024.

    In late March 2025, the organizations announced that they had completed the due diligence phase and would be looking for a way forward. However, an article from The Salem News in June reported the health systems ended their affiliation discussions despite extensive efforts to make the partnership feasible, including seeking federal and state funding for capital investments.

    “Despite expressing strong support for rural healthcare and funding this project, the state government did not pass a budget with this appropriation included,” the article notes.

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